DS 14000 with Peristaltic Pump
Tablet Dissolution Test Apparatus

Dissolution testing is extensively done in the pharmaceutical industry to do the quality control of the drugs and to determine the dissolution rate of the tablets or capsules for drug development.

DS 14000 with Peristaltic Pump is designed as per the specifications recommended by international regulatory bodies, and it is flexible in catering to the future needs of the pharmaceutical industry. The tablet testing apparatus has a vessel configuration of 12+2 (6+1 & 6+1), which helps in the comparative studies of the drugs. The apparatus conducts the testing using two buffers (buffer changing) tending to the application of enteric coating tablets. The DS 14000 with Peristaltic Pump rinses the entire sampling path after each interval in order to eliminate the contamination and carryover effects.

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Standard Features of DS 14000 with Peristaltic Pump
  • User-friendly, complies with current USP, IP, BP, IP & EP and ASTM specifications.
  • Alphanumeric polyester soft keys for keyboard.
  • External vibration free Water Circulator for uniform water circulation with audible and low water level alarm.
  • Mono shaft design with automatic adjustment for 25 mm depth setting with easy changeover between Apparatus I & II eliminates routine height validation as per USP.
  • Paddles, Baskets and Vessels are laser marked with serial numbers for traceability.
  • Tablet dispenser drops 12 dosage form at single instance.
  • The conical shape low evaporation recovery lids reduces media loss during long run.
  • Facility to monitor Vessel temp, with DTS Technology (Digital Temperature Sensor)
Additional Features
  • Facility to RINSE the entire sampling path in between sampling time points to reduce contamination & carryover
  • Specially developed cleaning system to clean the entire sampling path after each run.
  • Facilities to perform the dissolution test using two buffers (Buffer changing) to cater the application of enteric coating tablets.
  • Recovery Test facility to study 100% Drug Dissolution.
  • Split & on-time interval
Intelligent Sampling System
  • Automated sampling as per USP Specifications. Sampling tubes are lowered in the media only at the time of sampling and withdrawn immediately after sampling, thus no par t of the assembly contributes motion, agitation or vibration.
  • Sampling tubes are accurately moved to the USP sampling position i.e. a zone mid way between the surface of media and the top of paddle/basket parameters, not less than 1 cm from the vessels wall as selected in the method.
  • 12 bowls temperature monitoring system automatically measures and records the temperature of individual vessel at specified sample points.
Peristaltic Pump
  • Imported Pump with click-n-go Cassette design for volume accuracy.
  • Fixed length pump tubings with stopper for sampling volume accuracy.
  • Volume calibration through software.
  • Tygon pump tubings for SLS Compatibility with long life.
  • Imported Pump with Planetary drive for very accurate pumping.
  • High repeatability on all Channels.
  • 24 actively driven stainless steel rollers.
Sample Collection
  • 12 X 6 X 2 sets of samples can be collected. For more sampling interval, 24 X 6 collection trays are available.
  • Option of 1.5ml & 2ml HPLC vials is available.
  • Over Head Design for electronic safety and fail safe operation.
  • Sensor to locate proper position of tray with alar m facility for collection of sample Wide mouth vial to minimise SLS spill over problem due to foaming characteristics
  • Easy positioning with respect to vials or test tube tray for easy changeover
Software
  • Alphanumeric entries of Sample Name, Sample Number and Identification Number for authentication.
  • Built-in Real Time Clock (RTC) for date and time on display and on printout.
  • Daily Auto Incremented Run Number and factory entered CUSTOMER NAME with Instrument Serial Number on report printouts
  • Non-Volatile memory storage methods with parameters.
  • Two tier password protection of Admin and User
  • Reports can be obtained even after Resetting / Power off / Power failure conditions.
  • Error indication helps user to trace the problem.
  • Audible indication for ready state of instrument.
Regulatory Compliance
  • DS 14000 with Peristaltic Pump meets all requirements relating to validation, qualification and calibration.
  • Appropriate qualification documents (I.Q. / O.Q.) can be supplied with the instrument.
Dissolution Tester